Multiple sclerosis (MS) is a debilitating neuroinflammatory disease characterized by immune-mediated destruction of myelin in the CNS.  While immunomodulatory drugs have shown promise in treating early, relapsing-remitting forms of MS, we still lack a cure and nearly all MS patients eventually develop progressive forms of disease that are refractory to all current treatment approaches.  We are currently investigating the innate immune pathways and cell types that perpetuate progressive forms of MS disease and limit myelin repair.