Mounting evidence indicates key roles for the immune system in Alzheimer’s disease (AD). While recent advancements have been made in identifying immune receptors on the surface of cells that influence AD progression, we still lack knowledge of the intracellular messengers that instruct immune responses in AD. In our preliminary studies, we have identified a novel intracellular signaling pathway that is centrally involved in the disposal of neurotoxic agents and we further show that genetic deletion of this messenger results in worsened neurodegenerative disease. These findings suggest that therapeutics which activate this immune signaling pathway may offer novel strategies to limit Alzheimer’s disease progression.